New biocompatible heteropolimerni micellar systems of transportation and delivery of toxic and / or poorly soluble drug substances in living organisms
Індентифікаційний номер: OffersThe organization that specializes in particular in the development of modern nanotechnology for use in medicine, biology and pharmacology offers to introduce new biocompatible, heteropolimerni, micellar, systems, medicines, substances, organisms. The organization is looking for a strategic partner and / or investor for the further development of these systems, testing biological / protypuhlynnoyiaktyvnosti encapsulated in these drug substances, international patenting and implementation.
biocompatibility heteropolimerni, micellar, systems, medicines, substances, organisms
Опис пропозиції
It is known that only a third of drugs that are being developed in the world, comes to the use of specific pharmacological forms due to their high toxicity and / or poor solubility in water. So today in leading laboratories around the world involving chemists, biologists, doctors and pharmacists are actively developing various media medicinal substances that are capable of providing passive (nonspecific) and active (or intracellular targeted) drug delivery in the body. Using the media can encapsulate drug substance, to protect the body from its adverse toxic action to reduce unwanted immune response body converted into "soluble" form of poorly soluble substances, reduce the required therapeutic dose of drugs.
Today we know a vast range of media medicinal substances, such as liposomes and niosomy, polymeric micelles and vesicles, nano- and microparticles of polymers and inorganic materials, nano- and microcapsules. Among them, one of the leading places are micelles and vesicles heteropolymers (micellar nano konteyners, which have considerable advantages in comparison with others. Specifically, these micelles can be easily and in large quantities, their morphology, size and stability in solution can be easily managed by changing the chemical nature, the relative length and distribution of hydrophobic and hydrophilic blocks. Due to extremely low critical concentration micelle formation (CCM) and developed hydrophilic "corona" micelles heteropolymers show high stability in the medium body and low knowledge of the reticuloendothelial system of the liver and spleen, which contributes to their prolonged circulation in the bloodstream. Finally, on the surface of the micelles can easily create specific ligands ("vectors"), such as proteins, antibodies, fragments of polysaccharides to realize targeted delivery of drug substances in specific tissues and cells of living organisms.
The most common ways of forming micelles are: 1) self-assembly of macromolecules amphiphilic block and graft copolymers in selective solvents and 2) self-assembly intermolekulyar polycomplexes (InterPK) formed with copolymer block type.
We offer a range of innovative biocompatible micellar nano konteyners having a simple structure, high binding capacity for drug substances as hydrophilic and hydrophobic nature and, unlike micelles InterPK be destroyed under the influence of strong competitive interactions with place in a living organism. Structure, size and bonding ability of these micellar nano konteyners can easily manage the process of synthesis that does not require large energy and can be adjusted to any chemical / pharmaceutical company.
Tests of individual micellar nano konteyners in the delivery of anticancer drugs doxorubicin in vitro on cultures of cancer cells showed the possibility of reducing the active therapeutic dose, encapsulated in nano konteyners on average 5 times.
A collaboration that will bring development to implementation: investments, strategic partnerships, participation in international projects that will improve the status of development, etc. ...
Тип технології
Конструкція
Процес
Сфера застосування
In the field of modern nanotechnology for use in medicine, biology and pharmacology. Introduction of new biocompatible polymer hetero micellar systems of transportation and delivery of toxic and / or poorly soluble drug substances in living organisms.
Технічні та економічні переваги
Using the media can encapsulate drug substance, to protect the body from its adverse toxic action to reduce unwanted immune response body converted into "soluble" form of poorly soluble substances, reduce the required therapeutic dose of drugs.
On the surface micelles can easily create specific ligands ("vectors"), such as proteins, antibodies, fragments of polysaccharides to realize targeted delivery of drug substances in specific tissues and cells of living organisms.
Iнноваційні аспекти
A number of innovative biocompatible micellar nanocontainers, which have a simple structure, high binding capacity for drug substances as hydrophilic and hydrophobic nature and, unlike micelles InterPK be destroyed under the influence of strong competitive interactions take place in a living organism. Structure, size and bonding ability of micellar nanocontainers can be easily managed during their synthesis, which requires large power consumption and can be adjusted to any chemical / pharmaceutical company.
Де була представлена технологія
In vitro.
Практичний досвід застосування
Testing of individual micellar nanocontainers in the delivery of anticancer drugs doxorubicin in vitro on cultures of cancer cells showed the possibility of reducing the active therapeutic dose, encapsulated within nanocontainers, on average 5 times.
| Поточна стадія: | Є результати експериментальних досліджень |
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| Статус прав інтелектуальної властності: | Know-how |
Умови співпраці:
| Тип організації: | Strategic partnerships, international patenting and implementation and / or investments for further development of transportation systems and delivery of toxic and / or poorly soluble drug substances in living organisms, biological testing / antitumor activity encapsulated in these drug substances. |
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| Регіони: | Центральна Європа |
| Підтримка, що надається при передачі технічного проєкту: | Author's supervision. |
